Total Inhibition of Hepatic β-Lipoprotein Production in the Rat by Orotic Acid
نویسندگان
چکیده
منابع مشابه
Total inhibition of hepatic beta-lipoprotein production in the rat by orotic acid.
Lipoproteins of rat plasma have been characterized by lipid analysis, preparative ultracentrifugation, electrophoresis on paper, and immunoelectrophoresis with specific antisera to Lu-lipoprotein, P-lipoprotein, and whole rat plasma. Similar techniques were used to characterize the lipoproteins released by livers perfused in situ with a suspension of erythrocytes in a medium initially free of r...
متن کاملTotal Inhibition of Hepatic P-Lipoprotein Production in the Rat by Orotic Acid*
Lipoproteins of rat plasma have been characterized by lipid analysis, preparative ultracentrifugation, electrophoresis on paper, and immunoelectrophoresis with specific antisera to Lu-lipoprotein, P-lipoprotein, and whole rat plasma. Similar techniques were used to characterize the lipoproteins released by livers perfused in situ with a suspension of erythrocytes in a medium initially free of r...
متن کاملAn Orotic Acid-induced, Adenine-revereed Inhibition of Hepatic Lipoprotein Secretion in the Rat.
The induction of a severe fatty liver in rats by the addition of erotic acid to their purified diets was first reported by Standerfer and Handler (1). Creasey, Hankin, and Handschumacher (2) found that the liver fat was largely triglyceride and observed that its accumulation was both prevented and reversed by supplementing the erotic acid diets further with adenine (3). Marked alterations in th...
متن کاملAn Orotic Acid-induced, Adenine-reversed Inhibition of Hepatic Lipoprotein Secretion in the Rat
The induction of a severe fatty liver in rats by the addition of erotic acid to their purified diets was first reported by Standerfer and Handler (1). Creasey, Hankin, and Handschumacher (2) found that the liver fat was largely triglyceride and observed that its accumulation was both prevented and reversed by supplementing the erotic acid diets further with adenine (3). Marked alterations in th...
متن کاملDown-regulation of rat hepatic microsomal cytochromes P-450 in microvesicular steatosis induced by orotic acid.
Microvesicular steatosis is an important component of the overall pathogenesis of drug-mediated liver injury. Although mitochondrial damage has a role in the development of microvesicular steatosis, the consequences of fatty change for hepatic gene function are unclear. The present study was undertaken to evaluate hepatic cytochrome P-450 (CYP) function in a rat model of microvesicular steatosi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1967
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)96041-2